Prince Frederik, the youngest son of Luxembourg’s Prince Robert and Princess Julie, has passed away at the age of 22 after battling the rare genetic condition POLG Mitochondrial Disease. The heartbreaking news was announced by Prince Robert on social media and through The POLG Foundation, an organization founded by Frederik himself.
A Courageous Farewell
In an emotional statement, Prince Robert shared that Frederik’s final moments were filled with both wisdom and humor. “It is with a very heavy heart that my wife and I would like to inform you of the passing of our son, The POLG Foundation Founder and Creative Director, Frederik,” Robert wrote. He revealed that on February 28, fittingly on ‘Rare Disease Day,’ Frederik gathered his family one last time to say goodbye.
Frederik spent his final moments surrounded by his loved ones, including his brother, Alexander; his sister, Charlotte; his cousins, Charly, Louis, and Donall; his brother-in-law, Mansour; and his Aunt Charlotte and Uncle Mark. Robert noted that Frederik had already spoken privately with his mother before addressing the rest of the family. “After gifting each of us our farewells—some kind, some wise, some instructive—in true Frederik fashion, he left us collectively with a final long-standing family joke,” Robert wrote. “Even in his last moments, his humour, and his boundless compassion, compelled him to leave us with one last laugh… To cheer us all up.”
A Legacy of Advocacy and Awareness
Despite his young age, Prince Frederik left behind a remarkable legacy. As the founder and creative director of The POLG Foundation, he dedicated himself to raising awareness about mitochondrial diseases. His mission was to improve research and treatment for those diagnosed with the condition, which affects the body's ability to produce energy at a cellular level.
Understanding POLG Mitochondrial Disease
POLG-related mitochondrial diseases are caused by mutations in the POLG gene, which is essential for DNA replication in mitochondria. These mutations lead to a progressive decline in the body’s ability to produce energy, resulting in a range of severe symptoms, including muscle weakness, seizures, and organ failure. The disease is rare and often fatal, with no known cure.
Tributes and Mourning
The news of Prince Frederik’s passing has sent shockwaves through Luxembourg’s royal family and beyond. Tributes have poured in from both local and international dignitaries, honoring his efforts to bring attention to a devastating disease while demonstrating immense courage in his personal battle.
Prince Frederik’s passing is a profound loss, not just for the Luxembourg royal family but for the rare disease community worldwide. His dedication to The POLG Foundation and his advocacy work will continue to inspire those affected by mitochondrial diseases.
As Luxembourg mourns the loss of a young prince gone too soon, his legacy of resilience, humor, and unwavering compassion will undoubtedly live on.
